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Inderal pill size = 0.0005 mg/mL) and plasma (0.038 mg/mL). Both the and fecal metabolite levels were low (0.032 and 0.008 mg/mL) could not be detected by standard laboratory techniques. The concentration of oral contraceptive pill metabolite NNAL in the stool of 10 patients decreased dramatically after 1 month and peaked 4 months, with its lowest level at the end of study ( ). The clinical pattern varied among patients by the time periods during which they were studied. There patients in whom the NNAL level gradually increased in the fecal samples for weeks to months; this was observed in the women who had discontinued pill at 1 month, and it was also apparent in the women who had been taking the pills for more than 1 year. However, in patients who had been taking the pill for more than 1 year, the NNAL level in feces did not increase, consistent with oral contraceptive discontinuation. The levels of three major steroid hormone metabolites (estradiol, estrone, and pregnanediol) in the patients' fecal samples were analyzed at the end of study. There were only a few minor variations among the patients, and variability did not substantially exceed the typical variability of steroid hormone metabolite concentrations (see ). Documented gastrointestinal symptoms such as abdominal distention, dyspepsia, bloating and flatulence, diarrhea, nausea vomiting, increased blood pressure, flushing and redness around the eyes were observed in 20 women with polycystic ovary syndrome at the 8-week visit. No serious or unusual findings were found when data on adverse effects were examined for these women ( ). Other clinical examinations including an oral glucose tolerance test and electrocardiogram were consistent with the diagnosis of PCOS in these women, and there were no clinically significant abnormalities in the examinations. 10 other women, there were no obvious or clinically relevant clinical changes. In addition, all the women had normal thyroid function on bi-weekly stimulating hormone evaluation. Discussion This is the first prospective study to assess the effect of oral contraceptive pill on the concentrations of NNAL and its metabolite in the human feces. For each patient, only the metabolites that could be detected in the urine samples at a concentration lower than the limit of quantification (LOLR) were considered. The results show that after 8 weeks of taking the oral contraceptive Kamagra oral jelly kaufen ohne kreditkarte pill, in women with ovulatory disorders the concentrations of NNAL and its metabolite significantly increased over that time. The NNAL levels increased significantly even in women who had been taking the pill for at least 1 year. However, in those women who had been inderal dosage for mitral valve prolapse taking the pill for less than 1 year their levels declined. The results of this study suggest that NNAL concentrations in the feces after introduction of a new oral contraceptive pill may be an indicator for the continuation of oral contraceptive use and the duration of hormone-containing treatment. The study also has implications on the treatment of PCOS in women who have long-term oral contraceptive treatment. Although we could not confirm the results of studies NNAL levels in PCOS women that were progress, we hypothesize the increases in NNAL and its metabolite concentrations observed in women with PCOS after the introduction of a new oral contraceptive pill may affect the clearance of oestrogens, which may be involved in the pathogenesis of PCOS and might accelerate the progression to end of oestrogen treatment. avoid these effects, it would be essential to continue oral contraceptive therapy, and there is evidence that the women.
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