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Generic for digoxin ), as well a variety of other drugs that affect the heart. An FDA-approved clinical trial showed the drug could be safely used to treat people with heart failure. The drug is expected to make it into the next-generation heart bypass machine, which could be a life-saving addition to patient's treatment and potentially could reduce patient's heart failure risk by at least 50 percent in the early stages of disease. In October, the FDA approved two less intensive therapies for certain patients with heart failure, called ARBs. ARBs involve continuous infusion of medication over a short period of time, essentially providing a temporary but potent "high" as the infusion pushes toxic waste out of an impaired heart, allowing the heart to recover. first therapy, known as infusing epinephrine over 3 minutes with a pump, was approved for patients with an inability to stop or control their heart rhythm. The second regimen, called continuous-flow epinephrine infusion, was approved for patients who did not have an ability to stop their heart rhythm. In both cases, the therapies were not effective in preventing cardiac arrest. Both of those treatments are now FDA-approved for patients with heart failure and need to be given at different points of time in heart failure. But the new approval could allow all patients with heart failure, including those who can't be treated with traditional therapies, to be treated with the ARBs, said Dr. Rafi Shohamy, a cardiologist at St. Luke's Mid America Heart Institute in Kansas City, Missouri who was not involved with the new study. Shohamy is fluconazole generic equivalent not familiar with the study. "There is really much more interest in ARBs the early stages," Shohamy said. "This study is another indication that you can use ARBs safely to prevent heart failure." Heart failure is the most common cause of death in the United States and ninth leading cause of death in the Generic finasteride in us world. It's also leading cause of disability among older adults, with more than 2 million Americans having heart failure. This new study, published in the Nov. 8 issue of JAMA, showed that taking nimodipine (and possibly epinephrine) before and/or during heart failure reduced the chance of death by a third in patients with moderate-to-severe heart failure. The study was able to show this effect because when people in the study took nimodipine first few days of their disease, it reduced the risk of death from heart failure by 42 percent. Nodipine was generally well-tolerated, so the benefits of using drug persisted and even improved over time. "This drug has potential to be used treat all heart failure patients," said Dr. Peter J. Stavros, director of the New York Heart Association Health and Nutrition Program. He noted that the study did not look at patients who had severe-to-profound heart failure, which is more commonly treated with drugs such as beta blockers. "These patients don't respond to these drugs," Stavros said. The study's results make sense given what's known about these type of drugs, but they are not conclusive, Stavros said. For instance, if doctors stopped giving the drug quickly, would not seem effective. And it's also difficult to know whether the treatment actually helped people, because they changed their medications and had heart attacks strokes that may have affected the results. The study also did not look specifically at patients with heart failure in whom medication therapy was ineffective. And because the drug can increase blood pressure, it have an adverse effect on heart failure patients with underlying disease, said Shohamy. "The study's results are compelling, given the benefits, but we want to see them in larger and more rigorous studies for patients with greater clinical severity," said Dr. Robert L. Leventhal, chairman of cardiology at Yale University School of Medicine. Other research supports the use of nimodipine in people with heart failure. fact, two small randomized trials published this year in the New England Journal of Medicine found nimodipine to reduce heart failure patients' risk of death by more than 50 percent when compared with usual care or medication therapy when the drug was administered every three months. This type of drug is now considered an acceptable and effective therapy for treatment of moderate-to-severe heart failure. But the drug is not for everyone. "Patients in heart failure need to be taken very seriously and only recommended to see a cardiologist if there is serious reason," Shohamy said. "So many patients have no symptoms and a very good quality of life, but they end up requiring this drug because otherwise, they could simply go home at the end of day and get up go back to their life." A recent study at Baylor College of Medicine in Houston, Texas, the effectiveness of.
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